报告题目: Mechanobiological Insights into the Patho-physiology of Human Diseases
报 告 人: Professor LIM Chwee Teck (林水徳）
              Mechanobiology Institute, Division of Bioengineering & Department of Mechanical Engineering,
              National University of Singapore
报告时间: 2010年9月10日（星期五）上午10时
报告地点: 文选医学大楼 四楼会议室
Abstract：During the onset of a disease, a cell may experience alterations in both the composition and organization of its cellular structures. These alterations may eventually manifest as changes in the mechanical properties of the cell such as deformability and cell adhesion. With the recent advancements in micro/nanotechnology and biophysical techniques, we can now probe and study mechanical property changes in individual cells and even proteins.  In fact, knowing the effect of mechanical forces acting on cells can reveal ways by which diseased cells differ from healthy ones. This can help us better understand and establish possible connections between change in mechanical properties of cells and the onset and progression of human diseases. Here, we will highlight studies on two human diseases – malaria and cancer using nanotechnological and biophysical techniques such as laser tweezers, atomic force microscopy, microfluidics, cell migration and cell adhesion assays among others.  From these studies, we have also developed several new and novel microfluidic devices for disease detection of which one of them has been commercialized.