报告题目：Biotechnology Paradigm Shift: From Living Microorganisms to Cell-Free Biosystems
报 告 人：Y.-H. Percival Zhang , Ph.D.
Biological Systems Engineering Department,Virginia Tech,304 Seitz Hall,Blacksburg,Virginia 24061,USA
Abstract：Cell-free biosystems for manufacturing (CFBM) are the implementation of complicated biological reactions via the in vitro assembly of numerous (stable) enzymes originated from different sources and/or (biomimetic) cofactors 1-5. CFBM features numerous industrial production advantages: high product yield, fast reaction rate, easy access and control for open systems, tolerance of toxic compounds, broad reaction conditions, and so on. In this talk, I will present numerous CFBM examples, for example, the theoretical yield hydrogen production from sugars (e.g., pentoses and hexoses) 6-8, enzymatic conversion of cellulose to starch (amylose) 9, and (iii) super-energy density sugar-powered biobatteries. CFBM would become a high-yield and low-cost manufacturing platform and lead to a biotechnology paradigm shift, especially in the sustainability revolution pertaining to the energy-water-food nexus 10,11.